細胞制御工学研究センターコロキウム0040

シカゴ大学の Xiaoyang Wu博士に、表皮幹細胞を用いた細胞工学的研究について発表していただきます。

どうぞご参加ください。

概要

講師

Dr. Xiaoyang Wu
（Ben May Department for Cancer Research, The University of Chicago）

演題

Skin engineering with epidermal stem cells

要旨

Gene therapy with adult stem cells isolated from skin can be used for treatment of a variety of otherwise terminal or severely disabling diseases. However, development of clinically relevant skin stem cell therapy remains challenging to the field due to lack of a good animal model to test the efficacy and safety of potential therapy in vivo. We have now resolved the technical hurdles and developed a new mouse model for skin stem cell therapy. With this novel platform, we have explored the feasibility and clinical potential of skin gene therapy. Our results will provide an important proof-of-concept and serve as the basis for development of effective therapeutic strategies with skin stem cells targeting various diseases in the future.

参考論文

1. 1.Li Y, Kong Q, Yue J, Gou X, Xu M, Wu X. Nature Biomedical Engineering.
   Protection against cocaine-seeking and acute overdose by genome-edited epidermal stem cells. 2018, in press.
2. 2.Yue J, Gou X, Li Y, Wicksteed B, Wu X. Cell stem cell.
   Treatment of obesity and diabetes with CRISPR-mediated genome editing in epidermal stem cells. 2017 Aug 3; 21:256-263.
3. 3.Lee P, Jiang S, Li Y, Yue J, Gou X, Chen SY, Zhao Y, Schober M, Tan M, Wu X. EMBO Journal,
   Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis. 2017 May 15. PMID: 28507225.
4. 4.Yue J, Xie M, Gou X, Lee P, Schneider MD, Wu X. Developmental Cell.
   Microtubules regulate focal adhesion dynamics through MAP4K4. 2014 Dec 8;31(5):572-85. PubMed PMID: 25490267; PubMed Central PMCID: PMC4261153.

• 細胞制御工学研究センターコロキウム 0040 ポスター
• 科学技術創成研究院（IIR）
• 科学技術創成研究院 細胞制御工学研究センター