Life Science and Technology News

【Labs spotlight】 Nikaido Laboratory

Understanding the biodiversity at the DNA level

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November 21, 2016

The Department has a variety of laboratories for Life Science and Technology, in which cutting-edge innovative research is being undertaken not only in basic science and engineering but also in the areas of medicine, pharmacy, agriculture, and multidisciplinary sciences.

This "Spotlight" series features a laboratory from the Department and introduces you to the laboratory's research projects and outcomes. This time we focus on Nikaido Laboratory.

Associate Professor Masato Nikaido

Department of Biological Sciences
Associate Professor Masato Nikaidoouter

Keywords Adaptive evolution, Comparative genome, Vertebrates, Parallel evolution
Website Nikaido Laboratory (Japanese) outer

Research findings

Selected publications
[1] Suzuki H, Nikaido M, Hagino-Yamagishi K, Okada N (2015) Distinct functions of two olfactory marker protein genes derived from teleost-specific whole genome duplication. BMC Evol. Biol. 15:e245.
[2] Brawand D et al. (Nikaido M, 45/75) (2014) The genomic substrate for adaptive radiation in African cichlid fish. Nature 513:375-381.
[3] Nikaido M, Ota T, Hirata T, Satta Y, Saito Y, Aibara M, Mzighani SI, Hagino-Yamagishi K, Sturmbauer C, Okada N. (2014) Multiple episodic evolution events in V1R receptor genes of East-African cichlids. Genome Biol. Evol. 6:1135-1144.
[4] Nikaido M et al. (27 co-authors) (2013) Coelacanth genomes reveal signatures for evolutionary transition from water to land. Genome Res. 23:1740-1748.
[5] Nikaido M, Suzuki H, Toyoda A, Fujiyama A, Hagino-Yamagishi K, Kocher TD, Carleton KL, Okada N. (2013) Lineage specific expansion of V2R receptor (OlfC) genes in cichlids may contribute to diversification in amino acid detection. Genome Biol. Evol. 5: 711-722.
[6] Nikaido M, Sasaki T, Emerson JJ, Aibara M, Mzighani SI, Budeba YL, Ngatunga BP, Iwata M, Abe Y, Li W-H, Okada N. (2011) Genetically distinct coelacanth population off the northern Tanzanian coast. Proc. Natl. Acad. Sci. U. S. A. 108:18009-18013.
[7] Nikaido M, Piskurek O and Okada N. (2007) Toothed whale monophyly reassessed by SINE insertion analysis: the absence of lineage sorting effects suggests a small population of a common ancestral species. Mol. Phylogenet. Evol. 43:216-224.
[8] Nikaido M, Hamilton H, Makino H, Sasaki T, Takahashi K, Goto M, Kanda N, Pastene LA, and Okada N (2006) Baleen whale phylogeny and a past extensive radiation event revealed by SINE insertion analysis. Mol. Biol. Evol. 23:866-873.
[9] Nikaido M, Cao Y, Harada M, Okada N, Hasegawa M. (2003) Mitochondrial phylogeny of hedgehogs and monophyly of Eulipotyphla. Mol. Phylogenet. Evol. 28:276-284.
[10] Nikaido M, Nishihara H, Fukumoto Y, Okada N. (2003) Ancient SINEs from African Endemic Mammals. Mol. Biol. Evol. 20:522-527.
[11] Nikaido M, Kawai K, Cao Y, Harada M, Tomita S, Okada N, Hasegawa M. (2001) Maximum likelihood analysis of the complete mitochondrial genomes of eutherians and a reevaluation of the phylogeny of bats and insectivores. J. Mol. Evol. 53:508-516.
[12] Nikaido M, Matsuno F, Hamilton H, Brownell Jr. LR, Cao Y, Ding W, Zuoyan Z, Shedlock AM, Fordyce RE, Hasegawa M, Okada N. (2001) Retroposon analysis of major cetacean lineages: the monophyly of toothed whales and the paraphyly of river dolphins. Proc. Natl. Acad. Sci. U. S. A. 98:7384-7389.
[13] Nikaido M, Harada M, Cao Y, Hasegawa M, Okada N. (2000) Monophyletic origin of the order chiroptera and its phylogenetic position among mammalia, as inferred from the complete sequence of the mitochondrial DNA of a Japanese megabat, the Ryukyu flying fox (Pteropus dasymallus). J. Mol. Evol. 51:318-328.
[14] Nikaido M, Rooney AP, Okada N. (1999) Phylogenetic relationships among cetartiodactyls based on insertions of short and long interpersed elements: hippopotamuses are the closest extant relatives of whales. Proc. Natl. Acad. Sci. U. S. A. 96:10261-10266.


Associate Professor Masato Nikaido
Room 612, W3 building, Ookayama campus
E-mail :

*Find more about the lab and the latest activities at the lab site (Japanese)outer.

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