【研究室紹介】 小倉研究室

生命理工学系にはライフサイエンスとテクノロジーに関連した様々な研究室があり、基礎科学と工学分野の研究のみならず、医学や薬学、農学等、幅広い分野で最先端の研究が活発に展開されています。

研究室紹介シリーズでは、ひとつの研究室にスポットを当てて研究テーマや研究成果を紹介。今回は、医療応用を目指した生化学を展開する、小倉研究室です。

研究紹介

がんの代替療法と診断法の開発

バイオマーカーの開発

細胞生理工学の展開

研究成果

代表論文

• [1] Taku Nakayama, Shimpei Otsuka, Tatsuya Kobayashi, Hodaka Okajima, Kentaro Matsumoto, Yuichiro Hagiya, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy, Scientific Reports, 2016, 6, 36478.
• [2] Shimpei Otsuka, Kentaro Matsumoto, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura Oxygen availability for porphyrin biosynthesis enzymes determines the production of protoporphyrin IX (PpIX) during hypoxia, PLoS ONE, 2015, 10, e0146026.
• [3] Mai Miura, Kensuke Ito, Maiko Hayashi, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura The effect of 5-aminolevulinic acid on cytochrome P450-mediated prodrug activation, PLoS ONE, 2015, 10, e0131793.
• [4] Maiko Hayashi, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Yuichiro Hagiya, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid, PLoS ONE, 2015, 10, e0122351.
• [5] Kentaro Matsumoto, Yuichiro Hagiya, Yoshio Endo, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura Effects of plasma membrane ABCB6 on 5-aminolevulinic acid (ALA)-induced porphyrin accumulation in vitro: Tumor cell response to hypoxia, Photodiagnosis and Photodynamic Therapy, 2015, 12, 45-51.
• [6] Urara Ota, Hideo Fukuhara, Masahiro Ishizuka, Fuminori Abe, Chiaki Kawada, Kenji Tamura, Tohru Tanaka, Keiji Inoue, Shun-ichiro Ogura and Taro Shuin Plasma protoporphyrin IX following administration of 5-aminolevulinic acid as a potential tumor marker, Molecular and Clinical Oncology, 2015, 3, 797-801.
• [7] Kohei Yamashita, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation, FEBS Open Bio, 2014, 4, 347-352.
• [8] Yuta Sugiyama, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura* The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis, Oncology Reports, 2014, 31, 1282-1286.
• [9] Atsushi Shimoyama, Hiroya Watase, Yu Liu, Shun-Ichiro Ogura, Yuichiro Hagiya, Kiwamu Takahashi, Katsushi Inoue, Tohru Tanaka, Yasutoshi Murayama, Eigo Otsuji, Akihiro Ohkubo and Hideya Yuasa Access to a novel near-infrared photodynamic therapy through the combined use of 5-aminolevulinic acid and lanthanide nanoparticles, Photodiagnosis and Photodynamic Therapy, 2013, 10, 607-614.
• [10] Keiji Inoue, Urara Ota, Masahiro Ishizuka, Chiaki Kawada, Hideo Fukuhara, Taro Shuin, Ichiro Okura, Tohru Tanaka and Shun-ichiro Ogura Porphyrins as urinary biomarkers for bladder cancer after 5-aminolevulinic acid (ALA) administration: The potential of photodynamic screening for tumors, Photodiagnosis and Photodynamic Therapy, 2013, 10, 484-489.
• [11] Yuichiro Hagiya, Hideo Fukuhara, Kentaro Matsumoto, Yoshio Endo, Motowo Nakajima, Tohru Tanaka, Ichiro Okura, Atsushi Kurabayashi, Mutsuo Furihata, Keiji Inoue, Taro Shuin and Shun-ichiro Ogura Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer, Photodiagnosis and Photodynamic Therapy, 2013, 10, 288-295.
• [12] Tomohisa Hirano, Yuichiro Hagiya, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Kentaro Matsumoto, Katsushi Inoue, Tohru Tanaka, Ichiro Okura and Shun-ichiro Ogura* Improvement of aminolevulinic acid (ALA)-mediated photodynamic diagnosis using n-propyl gallate, Photodiagnosis and Photodynamic Therapy, 2013, 10, 28-32.
• [13] Yuichiro Hagiya, Yoshio Endo, Yutaka Yonemura, Kiwamu Takahashi, Masahiro Ishizuka, Fuminori Abe, Tohru Tanaka, Ichiro Okura, Motowo Nakajima, Toshihisa Ishikawa and Shun-ichiro Ogura Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro, Photodiagnosis and Photodynamic Therapy, 2012, 9, 204-214.
• [14] Masahiro Ishizuka, Yuichiro Hagiya, Yasuhiro Mizokami, Kanako Honda, Kenji Tabata, Toshiaki Kamachi, Kiwamu Takahashi, Fuminori Abe, Tohru Tanaka, Motowo Nakajima, Shun-ichiro Ogura and Ichiro Okura Porphyrins in mouse urine after administration of 5-aminolevulinic acid as a potential tumor marker, Photodiagnosis and Photodynamic Therapy, 2011, 8, 328-331.
• [15] Shun-ichiro Ogura, Kouji Maruyama, Yuichiro Hagiya, Yuta Sugiyama, Kyoko Tsuchiya, Kiwamu Takahashi, Fuminori Abe, Kenji Tabata, Ichiro Okura, Motowo Nakajima and Tohru Tanaka The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver, BMC Research Notes, 2011, 4, 66.

教員紹介

小倉俊一郎 准教授 博士（工学）

所属学会

日本化学会、日本癌学会、日本生化学会、ポルフィリンALA学会

教員からのメッセージ

• 研究室と研究テーマ
• 高大連携サマーチャレンジ2015開催報告｜東工大ニュース
• 平成26年度東工大挑戦的研究賞 受賞者決定｜東工大ニュース
• 熱帯熱マラリア原虫に対する5-アミノレブリン酸と鉄の相乗的な増殖阻害メカニズムを解明｜東工大ニュース
• ALA にがんの温熱療法の増強効果を発見｜東工大ニュース
• 広がるバイオの世界｜東京工業大学 高校生・受験生サイト

※この内容は掲載日時点の情報です。最新の研究内容については研究室サイトをご覧ください。