- Frank Uhlman博士（フランシスクリック研究所、The Francis Crick Institute, London, UK）
- Chromatin and Chromosomes, the Role and Function of SMC Proteins
- Packing genomic DNA into the eukaryotic cell nucleus is a task similar to stowing the London Underground network in a suitcase. Centimetres of DNA are compacted into micrometre-sized, rod-shaped chromosomes. This allows genetic material to be made small enough for faithful segregation to opposite cell halves, and compact enough to withstand the forces generated during this process. Over the past two decades, members of the evolutionarily ancient 'Structural Maintenance of Chromosomes (SMC)' family of protein complexes have emerged as principal structural chromosome components. We will discuss the mechanism of how these ring-shaped protein complexes encircle DNA, helped by a loading factor whose mutation causes severe human developmental disorders. We will also discuss models of how dynamic interactions between SMC binding sites might achieve the enormous DNA packaging task, providing an image of what the inside of a chromosome might look like.
今回の講師である Frank Uhlmann博士は、染色体分配制御の研究の第一人者で、科学技術創成研究院WRHIの特任教授として、8月末まで東工大に滞在されてます。
細胞制御工学研究センターコロキウム 0018 ポスター