Life Science and Technology News

Labs spotlight #43 - Fujii and Ishiuchi Laboratory -

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April 10, 2017

The Department has a variety of laboratories for Human Centered Science and Biomedical Engineering, in which cutting-edge innovative research is being undertaken not only in basic science and engineering but also in the areas of medicine, pharmacy, agriculture, and multidisciplinary sciences.

This "Spotlight" series features a laboratory from the Department and introduces you to the laboratory's research projects and outcomes. This time we focus on Fujii Laboratory.

Professor Masaaki Fujii and Associate Professor Shun-ichi Ishiuchi

Human Centered Science and Biomedical Engineering
Professor Masaaki Fujiiouter and Associate Professor Shun-ichi Ishiuchiouter

Degree Professor Masaaki Fujii : Dr. Sci. 1988, Tohoku University
Associate Professor Shun-ichi Ishiuchi : Dr. Sci. 2001, The Graduate University for Advanced Studies
Areas of Research Laser spectroscopy and Applications, Molecular Spectroscopy, Molecular Clusters, Photochemistry, Biomolecular Spectroscopy in Gas Phase
Keywords Hydrogen-bonded Clusters, Molecular Recognition, Neurotransmitters, Catecholamine, Peptides, Photo-Induced Dynamics
Website Fujii and Ishiuchi Laboratory (Japanese)outer

Research interest

Structure and dynamics of molecular clusters in gas phase

  1. a.Ionization induced solvent migration
  2. b.Excited state proton / hydrogen atom transfer
  3. c.Ground state proton transfer in solvated clusters

Biomolecular spectroscopy in gas phase

  1. a.Conformational reduction of catecholamine
  2. b.Structure of partial peptide of receptors
  3. c.Bottom-up approach toward understanding molecular, recognition mechanism in biological systems
  4. d.Conformational effect of alkaline metal complex upon, neutrtransmitters

Research interest

Research findings

Selected publications

  • [1] "Conformational study of protonated noradrenaline by UV-UV and IR dip double resonance laser spectroscopy combined with an electrospray and a cold ion trap methods", Hiromichi Wako, Shun-ichi Ishiuchi, Daichi Kato, Géraldine Feraud, Claude Dedonder-Lardeux, Christophe Jouvet, and Masaaki Fujii, Phys. Chem. Chem. Phys., (2017) in press.
  • [2] "High-cooling-efficiency cryogenic quadrupole ion trap and UV-UV hole burning spectroscopy of protonated tyrosine", Shun-ichi Ishiuchi, Hiromichi Wako, Daichi Kato, and Masaaki Fujii, J. Mol. Spectrosc., 332, 45-51 (2016).
  • [3] "Anharmonic Vibrational Analyses of Pentapeptide Conformations Explored with Enhanced Sampling Simulations", Hiroki Otaki, Kiyoshi Yagi, Shun-ichi Ishiuchi, Masaaki Fujii and Yuji Sugita, J. Chem. Phys. B, 120 (39), 10199-10213 (2016).
  • [4] "Photoionization-induced π ↔ H site switching dynamics in phenol+-Rg (Rg = Ar, Kr) dimers probed by picosecond time-resolved infrared spectroscopy", Mitsuhiko Miyazaki, Yuri Sakata, Markus Schütz, Otto Dopfer and Masaaki Fujii, Phys. Chem. Chem. Phys., 18 (35), 24746-24754 (2016).
  • [5] "Theoretical Study on the Size Dependence of Ground-State Proton Transfer in 1-Naphthol-Ammonia Clusters", Toshihiko Shimizu, Mitsuhiko Miyazaki and Masaaki Fujii, J. Phys. Chem. A, 120 (36), 7167-7174 (2016).
  • [6] "Gas phase ultraviolet and infrared spectroscopy on a partial peptide of β2-adrenoceptor SIVSF-NH2 by a laser desorption supersonic jet technique", Shun-ichi Ishiuchi, Kohei Yamada, Hikari Oba, Hiromichi Wako and Masaaki Fujii, Phys. Chem. Chem. Phys., 18 (33), 23277-23284 (2016).
  • [7] "Probing Solvation Dynamics around Aromatic and Biological Molecules at the Single-Molecular Level", Otto Dopfer and Masaaki Fujii, Chemical Reviews, 116(9), 5432-5463 (2016).
  • [8] "Electron-Proton Decoupling in Excited State Hydrogen Atom Transfer in the Gas Phase", Mitsuhiko Miyazaki, Ryuhei Ohara, Kota Daigoku, Kenro Hashimoto, Jonathan R. Woodward, Claude Dedonder, Christophe Jouvet and Masaaki Fujii, Angew. Chem/ Int. Ed., 54(50), 15089-15093 (2015).
  • [9] "Single Water Solvation Dynamics in the 4-Aminobenzonitrile-Water Cluster Cation Revealed by Picosecond Time-Resolved Infrared Spectroscopy", Mitsuhiko Miyazaki, Takashi Nakamura, Matthias Wohlgemuth, Roland Mitrić, Otto Dopfer and Masaaki Fujii, Phys. Chem. Chem. Phys., 17(44), 29969-29977 (2015).
  • [10] "Real time observation of the excimer formation dynamics of a gas phase benzene dimer by picosecond pump-probe spectroscopy", Mitsuhiko Miyazaki and Masaaki Fujii, Phys. Chem. Chem. Phys.s, 17(39), 25989-25997 (2015).
  • [11] "Solvation Dynamics of a Single Water Molecule Probed by Infrared Spectra — Theory Meets Experiment", Matthias Wohlgemuth, Mitsuhiko Miyazaki, Martin Weiler, Makoto Sakai, Otto Dopfer, Masaaki Fujii, and Roland Mitric', Angew. Chem. Int. Ed., 53(52), 14601-14604 (2014).
  • [12] "Mass Analyzed Threshold Ionization Detected Infrared Spectroscopy: Isomerization Activity of the Phenol-Ar Cluster near the Ionization Threshold", Mitsuhiko Miyazaki, Shunpei Yoshikawa, François Michels, Kentaro Misawa, Shun-ichi Ishiuchi, Makoto Sakai, Otto Dopfer, Klaus Müller-Dethlefs, and Masaaki Fujii, Phys. Chem. Chem. Phys., 17(4), 2949-2503 (2015).
  • [13] "Solvent Migration in Microhydrated Aromatic Aggregates:Ionization-Induced Site Switching in the 4-Aminobenzonitrile-Water Cluster", Takashi Nakamura, Matthias Schmies, Alexander Patzer, Mitsuhiko Miyazaki, Shunichi Ishiuchi, Martin Weiler, Otto Dopfer, and Masaaki Fujii, Chem. Euro. J., 20(7), 2031-2039 (2014).
  • [14] Revised conformational assignments and conformational evolution of tyrosine by laser desorption supersonic jet laser spectroscopy", Yoko Shimozono, Kohei Yamada, Shun-ichi Ishiuchi, Koichi Tsukiyama, and Masaaki Fujii, Phys. Chem. Chem. Phys., 15(14), 5163-5175 (2013) .
  • [15] "Watching Water Migration around a Peptide Bond", Kohei Tanabe, Mitsuhiko Miyazaki, Matthias Schmies, Alexander Patzer, Markus Schütz, Hiroshi Sekiya, Makoto Sakai, Otto Dopfer, and Masaaki Fujii. Angew. Chem. Int. Ed. 51 (27), 6604-6607 (2012).
  • [16] "Ionisation-induced site switching dynamics in solvated aromatic clusters: phenol-(rare gas)n clusters as prototypical example", Masaaki Fujii and Otto Dopfer.Int. Rev. Phys. Chem., 31(1), 131-173 (2012).
  • [17] "Photoionization-induced large-amplitude pendular motion in phenol(+)-Kr", Mitsuhiko Miyazaki, A. Takeda, Shun-ichi Ishiuchi, Makoto Sakai, Otto Dopfer, and Masaaki Fujii., Phys. Chem. Chem. Phys., 13 (7), 2744-2747 (2011).
  • [18] "Conformational reduction of DOPA in the gas phase studied by laser desorption supersonic jet laser spectroscopy", Shun-ichi Ishiuchi, H. Mitsuda, T. Asakawa, Mitsuhiko Miyazaki, and Masaaki Fujii., Phys. Chem. Chem. Phys., 13 (17), 7812-7820 (2011).
  • [19] "Gas-Phase Spectroscopy of Synephrine by Laser Desorption Supersonic Jet Technique", Shun-ichi Ishiuchi, T. Asakawa, H. Mitsuda, Mitsuhiko Miyazaki, Shamik Chakraborty, and Masaaki Fujii., J. Phys. Chem. A, 115 (37), 10363-10369 (2011).
  • [20] "Evidence for Catechol Ring-Induced Conformational Restriction in Neurotransmitters", Haruhiko Mitsuda, Mitsuhiko Miyazaki, Iben B. Nielsen, Pierre ÇarÇabal, Claude Dedonder, Christophe Jouvet, Shun-ichi Ishiuchi, and Masaaki Fujii., J. Phys. Chem. Lett., 1 (7), 1130-1133 (2010).


Professor Masaaki Fujii
Room 312, R1 building, Suzukakedai campus
E-mail :

Associate Professor Shun-ichi Ishiuchi
Room 310 or 316, R1 building, Suzukakedai campus
E-mail :

*Find more about the lab and the latest activities at the lab site (Japanese)outer.

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