Life Science and Technology News

Labs spotlight #21 - Ogura Laboratory -

Development of new medical biochemistry

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December 27, 2016

The Department has a variety of laboratories for Life Science and Technology, in which cutting-edge innovative research is being undertaken not only in basic science and engineering but also in the areas of medicine, pharmacy, agriculture, and multidisciplinary sciences.

This "Spotlight" series features a laboratory from the Department and introduces you to the laboratory's research projects and outcomes. This time we focus on Ogura Laboratory.

Associate Professor Shunichiro Ogura

Human Centered Science and Biomedical Engineering
Associate Professor Shunichiro OguraOuter

Degree PhD 2001, Tokyo Institute of Technology
Keywords Cancer diagnosis, Cancer therapy, Biomarker, Cell physiological engineering
Website

Ogura Laboratoryouter (Japanese)

Research interest

We develop the new biochemistry based on the analysis of metabolite from human and aim for the medical applications including cancer.

Research findings

Selected publications

  • [1] Taku Nakayama, Shimpei Otsuka, Tatsuya Kobayashi, Hodaka Okajima, Kentaro Matsumoto, Yuichiro Hagiya, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy, Scientific Reports, 2016, 6, 36478.
  • [2] Shimpei Otsuka, Kentaro Matsumoto, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura Oxygen availability for porphyrin biosynthesis enzymes determines the production of protoporphyrin IX (PpIX) during hypoxia, PLoS ONE, 2015, 10, e0146026.
  • [3] Mai Miura, Kensuke Ito, Maiko Hayashi, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura The effect of 5-aminolevulinic acid on cytochrome P450-mediated prodrug activation, PLoS ONE, 2015, 10, e0131793.
  • [4] Maiko Hayashi, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Yuichiro Hagiya, Motowo Nakajima, Tohru Tanaka and Shun-ichiro Ogura The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid, PLoS ONE, 2015, 10, e0122351.
  • [5] Kentaro Matsumoto, Yuichiro Hagiya, Yoshio Endo, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura Effects of plasma membrane ABCB6 on 5-aminolevulinic acid (ALA)-induced porphyrin accumulation in vitro: Tumor cell response to hypoxia, Photodiagnosis and Photodynamic Therapy, 2015, 12, 45-51.
  • [6] Urara Ota, Hideo Fukuhara, Masahiro Ishizuka, Fuminori Abe, Chiaki Kawada, Kenji Tamura, Tohru Tanaka, Keiji Inoue, Shun-ichiro Ogura and Taro Shuin Plasma protoporphyrin IX following administration of 5-aminolevulinic acid as a potential tumor marker, Molecular and Clinical Oncology, 2015, 3, 797-801.
  • [7] Kohei Yamashita, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation, FEBS Open Bio, 2014, 4, 347-352.
  • [8] Yuta Sugiyama, Yuichiro Hagiya, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka and Shun-ichiro Ogura* The heme precursor 5-aminolevulinic acid disrupts the Warburg effect in tumor cells and induces caspase-dependent apoptosis, Oncology Reports, 2014, 31, 1282-1286.
  • [9] Atsushi Shimoyama, Hiroya Watase, Yu Liu, Shun-Ichiro Ogura, Yuichiro Hagiya, Kiwamu Takahashi, Katsushi Inoue, Tohru Tanaka, Yasutoshi Murayama, Eigo Otsuji, Akihiro Ohkubo and Hideya Yuasa Access to a novel near-infrared photodynamic therapy through the combined use of 5-aminolevulinic acid and lanthanide nanoparticles, Photodiagnosis and Photodynamic Therapy, 2013, 10, 607-614.
  • [10] Keiji Inoue, Urara Ota, Masahiro Ishizuka, Chiaki Kawada, Hideo Fukuhara, Taro Shuin, Ichiro Okura, Tohru Tanaka and Shun-ichiro Ogura Porphyrins as urinary biomarkers for bladder cancer after 5-aminolevulinic acid (ALA) administration: The potential of photodynamic screening for tumors, Photodiagnosis and Photodynamic Therapy, 2013, 10, 484-489.
  • [11] Yuichiro Hagiya, Hideo Fukuhara, Kentaro Matsumoto, Yoshio Endo, Motowo Nakajima, Tohru Tanaka, Ichiro Okura, Atsushi Kurabayashi, Mutsuo Furihata, Keiji Inoue, Taro Shuin and Shun-ichiro Ogura Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer, Photodiagnosis and Photodynamic Therapy, 2013, 10, 288-295.
  • [12] Tomohisa Hirano, Yuichiro Hagiya, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Kentaro Matsumoto, Katsushi Inoue, Tohru Tanaka, Ichiro Okura and Shun-ichiro Ogura* Improvement of aminolevulinic acid (ALA)-mediated photodynamic diagnosis using n-propyl gallate, Photodiagnosis and Photodynamic Therapy, 2013, 10, 28-32.
  • [13] Yuichiro Hagiya, Yoshio Endo, Yutaka Yonemura, Kiwamu Takahashi, Masahiro Ishizuka, Fuminori Abe, Tohru Tanaka, Ichiro Okura, Motowo Nakajima, Toshihisa Ishikawa and Shun-ichiro Ogura Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro, Photodiagnosis and Photodynamic Therapy, 2012, 9, 204-214.
  • [14] Masahiro Ishizuka, Yuichiro Hagiya, Yasuhiro Mizokami, Kanako Honda, Kenji Tabata, Toshiaki Kamachi, Kiwamu Takahashi, Fuminori Abe, Tohru Tanaka, Motowo Nakajima, Shun-ichiro Ogura and Ichiro Okura Porphyrins in mouse urine after administration of 5-aminolevulinic acid as a potential tumor marker, Photodiagnosis and Photodynamic Therapy, 2011, 8, 328-331.
  • [15] Shun-ichiro Ogura, Kouji Maruyama, Yuichiro Hagiya, Yuta Sugiyama, Kyoko Tsuchiya, Kiwamu Takahashi, Fuminori Abe, Kenji Tabata, Ichiro Okura, Motowo Nakajima and Tohru Tanaka The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver, BMC Research Notes, 2011, 4, 66.

Contact

Associate Professor Shun-ichiro Ogura
Room 702, B1 building, Suzukakedai campus
E-mail : sogura@bio.titech.ac.jp

*Find more about the lab and the latest activities at the lab siteouter. (Japanese)

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