Cell Biology Center Colloquium 0021

Program

Lecturer

Prof. James E. Haber
(Director of Rosenstiel Basic Medical Sciences Research Center, Brandeis University, USA)

Title

The DNA damage response and DNA damage-induced autophagy

Abstract

In budding yeast, a single double-strand chromosome break is sufficient to trigger the DNA damage checkpoint response, causing cells to arrest prior to anaphase, providing time for cells to accomplish repair of the break. We are especially interested in how the checkpoint is turned off, either when breaks are repaired or when cells adapt and divide in spite of persistent damage. DNA damage also provokes an increase in protein degradation by autophagy. This Genotoxin Targeted Autophagy (GTA) is distinct from other autophagic pathways and requires the ATM and ATR kinases as well as several genes that are not implicated in starvation-induced autophagy.

There will be a seminar by Prof. James E. Haber (Director of Rosenstiel Basic Medical Sciences Research Center, Brandeis University, USA), who is working on homologous recombination and DNA double strand break repair in budding yeast. He is staying at Tokyo Tech until early November as a specially-appointed professor of IIR-WRHI. You are welcome to attend. See also the attached pdf.

• Cell Biology Center Colloquium 0021 flyer
• Institute of Innovative Research (IIR)